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KMID : 0379520120280040249
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한국독성학회지
2012 Volume.28 No. 4 p.249 ~ p.253
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Anti-inflammatory Effect of Bumblebee Alcohol Extracts in CFA-Induced Rat Edema
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Ahn Mi-Young
Han Jea-Woong
Yoon Hyung-Joo
Hwang Jae-Sam
Young Yun-Eun
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Abstract
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In this study, we prepared alcohol extracts of the larva, pupa, queen, and cocoon (clony) of B. ignitus, B. terrestris, and B. h. sapporoensis, and tested the anti-inflammatory activity of the extracts by using a rat model of adjuvant-induced edema. The extracts derived from the queen of B. ignitus, the queen of B. terrestris, and the cocoon of B. ignitus decreased hind paw edema after 1 day of i.p. administration. These extracts also induced vasorelaxation and NO production in calf pulmonary artery endothelial cells. These results suggest that bumblebee alcohol extracts has anti-inflammatory and vasorelaxant properties.
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KEYWORD
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Edema, Bumblebee alcohol extract
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